L.A. Reynolds and E.M. Tansey - The Recent History of Platelets in Thrombosis and Other Disorders

Description for L A Reynolds and E M Tansey The Recent History of Platelets in Thrombosis and Other Disorders

L.A. Reynolds and E.M. Tansey - The Recent History of Platelets in Thrombosis and Other Disorders
Publisher: Wellcome Trust Centre for the History of Medicine at UCL | 2005-07 | ISBN: 0854841032 | PDF | 186 pages | 1.62 MB

The recent history of research on platelets and its applications in medicine started with the introduction of ex vivo methods for studying platelet behaviour. The Witness Seminar held on 25 November 2003, chaired by Professor Tom Meade, considered the detailed study of platelets starting with the recognition of their role in haemostasis, both in thrombotic and bleeding disorders . Professor Gustav Born described his research and the invention and development of the optical aggregometer that bears his name. Other topics included the biochemistry and function of platelets ; the platelet release reaction and the effect of aspirin on it ; the Nobel Prize-winning discovery by Sir John Vane of how aspirin inhibits the natural production of prostaglandins; and results of randomized controlled trials of aspirin and other thrombolytic drugs for the prevention of thrombotic conditions. An appendix includes a discussion of the streptokinase trials, 1986-96, from the unpublished Witness Seminar meeting on Thrombolysis held on 28 January 2003, chaired by Professor Brian Pentecost.

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